Adding familial risk assessment to faecal occult blood test can increase the effectiveness of population-based colorectal cancer screening

Autor: Rosella P.M.G. Hermens, S.H. van Stiphout, Robert J.F. Laheij, M. G. H. van Oijen, W. A. G. van Zelst-Stams, L.G.M. van Rossum, M.W.J. van Vugt-van Pinxteren, Nicky Dekker, Nicoline Hoogerbrugge, Jan B.M.J. Jansen
Rok vydání: 2011
Předmět:
Male
Risk
Cancer Research
medicine.medical_specialty
Colorectal cancer
Hereditary cancer and cancer-related syndromes Genetics and epigenetic pathways of disease [ONCOL 1]
education
Population
Colonoscopy
Medical Oncology
Risk Assessment
Gastroenterology
Colorectal neoplasms
Feces
Translational research [ONCOL 3]
Internal medicine
medicine
Humans
False Positive Reactions
Risk factor
Familial risk
neoplasms
Early Detection of Cancer
Faecal occult blood test
Mass screening
Aged
Family Health
education.field_of_study
Hereditary cancer and cancer-related syndromes [ONCOL 1]
medicine.diagnostic_test
business.industry
Cancer
Middle Aged
medicine.disease
digestive system diseases
Hereditary cancer
Oncology
Evaluation of complex medical interventions [NCEBP 2]
Occult Blood
Quality of hospital and integrated care Quality of Care [NCEBP 4]
Female
Population Risk
Quality of hospital and integrated care [NCEBP 4]
Risk assessment
business
Zdroj: European Journal of Cancer, 47, 10, pp. 1571-7
European Journal of Cancer, 47, 1571-7
ISSN: 0959-8049
DOI: 10.1016/j.ejca.2011.01.022
Popis: Contains fulltext : 97608.pdf (Publisher’s version ) (Closed access) BACKGROUND: The Dutch Health Council recently recommended the introduction of a colorectal cancer (CRC) screening programme by faecal occult blood testing (FOBT) for individuals aged 55-75 at population risk of CRC. Individuals at an increased familial CRC risk (>/= 2 times population risk) should be identified at a younger age, so they and their relatives can receive earlier, more intensive surveillance instead of FOBT. AIMS: To determine the percentage of participants with a positive FOBT in a CRC screening programme with an increased familial CRC risk. METHODS: In a population-based study, 10,569 individuals aged 50-75 received an FOBT. Individuals with a positive FOBT were invited for colonoscopy and familial risk assessment. Participants with an average familial CRC risk were compared to those with an increased risk. Increased familial CRC risk was defined as a cumulative lifetime risk of CRC of at least 10%. RESULTS: Of 6001 participants, 430 had a positive FOBT, of whom 324 (63% males; mean age 63 years) completed colonoscopy and familial risk assessment. CRC (n=22) and/or advanced adenomas (n=122) were found in 133 participants. Familial CRC risk was increased in 6% of participants with a positive FOBT. No significant differences were found between participants with an average versus an increased familial CRC risk. CONCLUSION: Six percent of participants with a positive FOBT had an increased familial CRC risk. Identifying at-risk participants enables them and their relatives to undergo regular colonoscopies. Adding familial risk assessment to FOBT screening may thus prevent a substantial number of CRCs.
Databáze: OpenAIRE
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