Powerful Adrenergic Neurone-blocking Agents related to Choline 2,6-Xylyl Ether Bromide
| Autor: | A. McCoubrey, G. G. Coker, A. L. A. Boura, A. R. Elphick, A. F. Green, F. C. Copp, W. G. Duncombe |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Bromides
medicine.medical_specialty Sympathetic nervous system Multidisciplinary Blocking (radio) Adrenergic Blocking effect Ether Choline chemistry.chemical_compound Adrenergic Agents medicine.anatomical_structure Endocrinology chemistry Bromide Internal medicine Sympatholytics medicine Ethers Bretylium Tosylate |
| Zdroj: | Nature. 185:925-926 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/185925a0 |
| Popis: | THE discovery that the functioning of the post-ganglionic sympathetic adrenergic nerves could be impaired by choline 2,6-xylyl ether bromide (I), TM 10 (refs. l, 2), led to a search for compounds having a similar effect, but lacking the parasympathomimetic actions which preclude its use in man3. Such a selective blocking action was found in a series of benzyl quaternary ammonium salts4, and one of these, bretylium tosylate, was eventually shown to be a valuable antihypertensive agent in man5. This compound can depress conduction in various nerves, and the specificity of its blocking effect on the sympathetic nervous system seems to be related to its selective accumulation in adrenergic neurones (unpublished work). |
| Databáze: | OpenAIRE |
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