Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep
| Autor: | Ya-Wei Sun, Sangang He, Wei Du, Ming-Jun Liu, Zhang Zhifeng, Changyan Tian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Candidate gene Veterinary medicine Thoracic Vertebral Number biology.animal_breed Vertnin Gene lcsh:Animal biochemistry Single-nucleotide polymorphism Carcass Weight Lumbar vertebrae Quantitative trait locus Article 03 medical and health sciences Polymorphism (computer science) Genotype medicine lcsh:QP501-801 lcsh:SF1-1100 Sheep biology food and beverages Anatomy musculoskeletal system Animal Breeding and Genetics 030104 developmental biology medicine.anatomical_structure Lumbar Vertebral Number Animal Science and Zoology Texel sheep Gene polymorphism lcsh:Animal culture Carcass Length Food Science |
| Zdroj: | Asian-Australasian Journal of Animal Sciences Asian-Australasian Journal of Animal Sciences, Vol 30, Iss 9, Pp 1234-1238 (2017) |
| ISSN: | 1976-5517 1011-2367 |
| Popis: | Objective The vertebral number is associated with body length and carcass traits, which represents an economically important trait in farm animals. The variation of vertebral number has been observed in a few mammalian species. However, the variation of vertebral number and quantitative trait loci in sheep breeds have not been well addressed. Methods In our investigation, the information including gender, age, carcass weight, carcass length and the number of thoracic and lumbar vertebrae from 624 China Kazakh sheep was collected. The effect of vertebral number variation on carcass weight and carcass length was estimated by general linear model. Further, the polymorphic sites of Vertnin (VRTN) gene were identified by sequencing, and the association of the genotype and vertebral number variation was analyzed by the one-way analysis of variance model. Results The variation of thoracolumbar vertebrae number in Kazakh sheep (18 to 20) was smaller than that in Texel sheep (17 to 21). The individuals with 19 thoracolumbar vertebrae (T13L6) were dominant in Kazakh sheep (79.2%). The association study showed that the numbers of thoracolumbar vertebrae were positively correlated with the carcass length and carcass weight, statistically significant with carcass length. To investigate the association of thoracolumbar vertebrae number with VRTN gene, we genotyped the VRTN gene. A total of 9 polymorphic sites were detected and only a single nucleotide polymorphism (SNP) (rs426367238) was suggested to associate with thoracic vertebral number statistically. Conclusion The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238) with significant effect on thoracic vertebral number could be as a candidate marker to further evaluate its role in influence of thoracolumbar vertebral number. |
| Databáze: | OpenAIRE |
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