The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode

Autor: Ibrahim H. Kamal, Jessica Ingram, Mehul B. Ganatra, Elodie Ghedin, Shiliang Wang, Eugene Goltsman, Kiryl Tsukerman, Victor Joukov, Laurie S. Moran, Marina V. Omelchenko, Janos Posfai, Nikos C. Kyrpides, Barton E. Slatko, Kira S. Makarova, Jeremy M. Foster, Tamas Vincze, Jennifer Ware, Eugene V. Koonin, Natalia Ivanova, Alla Lapidus, Donald Comb, Anamitra Bhattacharyya, Vinayak Kapatral, Olga Ostrovskaya, Sanjay Kumar, Mikhail Mazur
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Nematodes
Evolution
QH301-705.5
Molecular Sequence Data
Genetics/Genomics/Gene Therapy
Genome
Microbiology
General Biochemistry
Genetics and Molecular Biology
Brugia malayi
Evolution
Molecular
03 medical and health sciences
Homo (Human)
parasitic diseases
Animals
Humans
Bioinformatics/Computational Biology
Biology (General)
Symbiosis
Genome size
Gene
Prophage
030304 developmental biology
Genetics
Comparative genomics
0303 health sciences
General Immunology and Microbiology
biology
030306 microbiology
General Neuroscience
Life Sciences
Gene Expression Regulation
Bacterial
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
Eubacteria
ComputingMethodologies_PATTERNRECOGNITION
Infectious Diseases
Membrane biogenesis
bacteria
Wolbachia
General Agricultural and Biological Sciences
Genome
Bacterial
Research Article
Zdroj: PLoS Biology, Vol 3, Iss 4, p e121 (2005)
Foster, Jeremy; Ganatra, Mehul; Kamal, Ibrahim; Ware, Jennifer; Makarova, Kira; Ivanova, Natalia; et al.(2005). The Wolbachia genome of Brugia malayi: Endosymbiont evolution within a human pathogenic nematode. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/7851x83p
PLoS Biology
ISSN: 1545-7885
1544-9173
Popis: Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi (wBm) with the Wolbachia endosymbiont of Drosophila melanogaster (wMel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to wMel, wBm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of wBm in contrast to the parasitic lifestyle of wMel. The smaller genome size of wBm, relative to wMel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease.
Analysis of this Wolbachia genome, which resides within filarial parasites, offers insight into endosymbiont evolution and the promise of new strategies for the elimination of human filarial disease
Databáze: OpenAIRE
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