Prevention of Acute Graft-Versus-Host-Disease by Selective Depletion of T Cells Reactive with Minor Histocompatibility Antigens on Epithelial Cells

Autor:	Van Dyk Am, Otten Hg, Verdonck Lf
Rok vydání:	2001
Předmět:	Cancer Research T-Lymphocytes medicine.medical_treatment Graft vs Host Disease Epithelial Cells chemical and pharmacologic phenomena Tumor cells T-cell depletion Hematology Hematopoietic stem cell transplantation Biology Lymphocyte Depletion Minor Histocompatibility Antigens Interleukin 21 surgical procedures operative Oncology immune system diseases Acute Disease Acute graft versus host disease Immunology medicine Minor histocompatibility antigen Animals Humans Cytotoxic T cell
Zdroj:	Leukemia & Lymphoma. 40:385-391
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428190109057938
Popis:	Graft-versus-host disease (GVHD) is a major obstacle in allogeneic hematopoietic stem cell transplantation (HSCT). Mature donor T-cells present in the graft play a pivotal role in the development of acute GVHD. On the other hand, mature donor T-cells in the graft are also crucial for the elimination of residual tumor cells still present in the patient after HSCT. Whether donor T cells act non-specifically against the patient, including an overlapping GVHD/GVL reactivity, or some donor T cells have GVHD reactivity while other donor T cells have GVL reactivity is still unclear. Some in-vitro data are suggestive that selective T cell depletion techniques are possible by which GVHD-reactive T cells can be eliminated while GVL-reactive T cells are preserved. Here we update some approaches of selective T cell depletion that have been developed in our laboratory.
Databáze:	OpenAIRE
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