The antihypertensive treatment effect on left ventricular diastolic function is reflected in exercise electrocardiogram
| Autor: | Christodoulos Stefanadis, Andreas P. Michaelides, Evaggelos I. Chatzistamatiou, Polychronis Dilaveris, Gregory P. Vyssoulis, Charalampos I. Liakos, Maria I. Markou |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Diastole Left ventricular hypertrophy Doppler imaging Electrocardiography Ventricular Dysfunction Left Risk Factors Internal medicine medicine Humans False Positive Reactions Prospective Studies Treadmill Prospective cohort study Exercise Antihypertensive Agents Aged ST depression business.industry Middle Aged medicine.disease Echocardiography Doppler medicine.anatomical_structure Blood pressure Hypertension Exercise Test Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Journal of Electrocardiology. 45:28-35 |
| ISSN: | 0022-0736 |
| Popis: | Exercise electrocardiographic hump sign is associated with uncontrolled arterial hypertension (AH), left ventricular (LV) diastolic dysfunction, and false-positive exercise testing (ET). The aim of this prospective study was to evaluate the antihypertensive treatment effect on hump and on pseudoischemic ST-segment depression and potential correlations to LV diastolic function and mass changes.The study comprised 59 non-coronary artery disease patients (45.9 years; 67.8% men) with never-treated arterial hypertension (143.2/95.1 mm Hg). Treadmill ET and echocardiography were performed at baseline and 6 months after pharmaceutical blood pressure normalization. Prevalence of hump and ST depression, transmitral (E/A) and tissue Doppler imaging (E'/A') early/late velocities ratios, E/E' ratio, and LV mass index (LVMI) were all defined.Prevalence of hump was reduced from 69.5% to 23.7% and false-positive ETs from 35.6% to 18.6% (P.05). Significant improvement (P.05) was found in E'/A' ratio (0.68 vs 0.84), E/E' ratio (9.3 vs 7.9), and LVMI (109.2 vs 99.8 g/m(2)). Changes in hump were related to ST-depression changes (r = 0.632, P.001) and to LV diastolic indices changes; patients with hump only at first ET (54.2%) improved E/A and E'/A' ratios, whereas patients with hump only at second ET (8.5%) worsened diastolic indices with similar changes in blood pressure and LVMI.Antihypertensive treatment reduces the prevalence of hump and exercise ischemic-appearing ST depression probably through LV diastolic function improvement. |
| Databáze: | OpenAIRE |
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