Family-Based Association Study of Synapsin II and Schizophrenia
| Autor: | Jianguo Shi, Qi Chen, David St Clair, Xinzhi Zhao, Yifeng Xu, Xinmin Liu, Qingying Chen, Wei Qin, Jin-huan Wang, Lin He, Guang He, Guoyin Feng, Yangling Xing, Min Li, Shiwei Duan |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Genetic Markers Male Candidate gene Linkage disequilibrium Psychosis China Genotype Biology Population stratification Polymorphism Single Nucleotide Genetic determinism Linkage Disequilibrium Gene Frequency Genetic linkage mental disorders medicine Genetics Humans Genetic Predisposition to Disease Genetics(clinical) Child Allele frequency Genetics (clinical) DNA Primers Family Health Haplotype Articles medicine.disease Synapsins Gene Components Haplotypes Schizophrenia Female |
| Zdroj: | The American Journal of Human Genetics. 75(5):873-877 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/425588 |
| Popis: | Synapsin II has been proposed as a candidate gene for vulnerability to schizophrenia on the basis of its function and its location in a region of the genome implicated by linkage studies in families with schizophrenia. We recently reported positive association of synapsin II with schizophrenia in a case-control study (Chen et al. 2004). However, since case-control analyses can generate false-positive results in the presence of minor degrees of population stratification, we have performed a replication study in 366 additional Han Chinese probands and their parents by use of analyses of transmission/disequilibrium for three in/del markers and three single-nucleotide polymorphisms. Positive association was observed for rs2307981 (P = .02), rs2308169 (P = .005), rs308963 (P = .002), rs795009 (P = .02), and rs2307973 (P = .02). For transmission of six-marker haplotypes, the global P value was .0000016 (5 degrees of freedom), principally because of overtransmission of the most common haplotype, CAA/−/G/T/C/− (frequency 53.6%; χ2 = 20.8; P = .0000051). This confirms our previous study and provides further support for the role of synapsin II variants in susceptibility to schizophrenia. |
| Databáze: | OpenAIRE |
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