The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall
| Autor: | Monique Braquet, L. Maes, R. Andries, Pierre Braquet, L. Touqui, R.H. Bourgain |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Pathology medicine.medical_specialty Endothelium Platelet Aggregation medicine.medical_treatment Guinea Pigs Inflammation Pharmacology In Vitro Techniques Biochemistry Guinea pig chemistry.chemical_compound Lactones Endocrinology In vivo medicine Animals Embolization Thrombus Alprostadil Platelet Activating Factor Edetic Acid Platelet-activating factor business.industry Plant Extracts Antagonist Thrombosis Arteries respiratory system medicine.disease Epoprostenol Adenosine Diphosphate Microscopy Electron medicine.anatomical_structure Ginkgolides chemistry Quinacrine Microscopy Electron Scanning lipids (amino acids peptides and proteins) medicine.symptom Diterpenes business |
| Zdroj: | Prostaglandins. 30(2) |
| ISSN: | 0090-6980 |
| Popis: | The effect of a topical paf-acether superfusion over an injured arterial segment was assessed in the guinea-pig, using an opto-electronic in vivo thrombosis model allowing on line quantification of small platelet thrombus dynamics. As compared to control, ADP-induced, thromboformation and behaviour, exogenous paf-acether causes a large, dense platelet thrombus, invaded and surrounded by numerous leukocytes, spreading widely over the adjoining, vacuolized, endothelium. Its embolization has to be forced with prostanoids, mepacrine, EDTA, or with a specific paf-acether antagonist3 (BN 52021). A few minutes after such forced embolization, a new thrombus starts growing at the same site, without renewal of the paf-acether superfusion. This phenomenon of spontaneous reappearance after forced embolization can be followed during several hours. Experiments with labelled paf-acether and the paf-acether antagonist indicate a possible endogenous paf-acether (or paf-acether-like) production triggered by superfusion with exogenous paf-acether. |
| Databáze: | OpenAIRE |
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