A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis
| Autor: | Suzan Thompson, Jim McNair, Claire Barry, Claus Aagaard, David N. McMurray, David Corbett, Samuel Strain, Lyanne McCallan, Peter Andersen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Article Subject
Badger 040301 veterinary sciences New infection Disease Meles 0403 veterinary science biology.animal medicine Mycobacterium bovis lcsh:Veterinary medicine General Veterinary biology business.industry Infectious dose 0402 animal and dairy science 04 agricultural and veterinary sciences biology.organism_classification 040201 dairy & animal science Virology 3. Good health medicine.anatomical_structure Immunology lcsh:SF600-1100 Lymph business Respiratory tract Research Article |
| Zdroj: | Veterinary Medicine International, Vol 2011 (2011) Veterinary Medicine International |
| ISSN: | 2042-0048 |
| Popis: | There is significant interest in developing vaccines to control bovine tuberculosis, especially in wildlife species where this disease continues to persist in reservoir species such as the European Badger (Meles meles). However, gaining access to populations of badgers (protected under UK law) is problematic and not always possible. In this study, a new infection model has been developed in ferrets (Mustela furo), a species which is closely related to the badger. Groups of ferrets were infected using a Madison infection chamber and were examined postmortem for the presence of tuberculous lesions and to provide tissue samples for confirmation ofMycobacterium bovisby culture. An infectious dose was defined, that establishes infection within the lungs and associated lymph nodes with subsequent spread to the mesentery lymph nodes. This model, which emphasises respiratory tract infection, will be used to evaluate vaccines for the control of bovine tuberculosis in wildlife species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text