Dynamic regulation of ERK2 nuclear translocation and mobility in living cells
| Autor: | Anusrhee Roy, Matilde Marchi, Lamberto Maffei, Gian Michele Ratto, Francesco Cardarelli, Fabio Beltram, Mario Costa |
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| Přispěvatelé: | Costa, Mario, Marchi, Matilde, Cardarelli, Francesco, Roy, Anusrhee, Beltram, Fabio, Maffel, Lamberto, Ratto, Glan Michele |
| Rok vydání: | 2006 |
| Předmět: |
MAPK/ERK pathway
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| Zdroj: | Journal of Cell Science. 119:4952-4963 |
| ISSN: | 1477-9137 0021-9533 |
| DOI: | 10.1242/jcs.03272 |
| Popis: | The extracellular signal-regulated protein kinase ERK1/2 is a crucial effector linking extracellular stimuli to cellular responses: upon phosphorylation ERK [also known as mitogen-activated protein kinase P42/P44 (MAPK)] concentrates in the nucleus where it activates specific programs of gene expression. Notwithstanding the importance of this process, little is known about the modalities, time course and regulation of ERK exchange between nucleus and cytoplasm in living cells. We visualized the dynamic of nuclear translocation by expressing low levels ( |
| Databáze: | OpenAIRE |
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