Effects of TNF-alpha inhibitors on the number of epidermal Langerhans cells in uninvolved skin of psoriatic patients: A pilot study
| Autor: | Anna Michelotto, Edoardo Zattra, Mauro Alaibac, Stefano Piaserico |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Histology Uninvolved skin Cell Count Pilot Projects Antibodies Monoclonal Humanized Receptors Tumor Necrosis Factor Etanercept Secondary lymphoid organs Psoriasis Humans Medicine Aged Skin Baseline values Tumor Necrosis Factor-alpha business.industry Adalimumab Antibodies Monoclonal Cell Biology General Medicine Middle Aged medicine.disease Infliximab Immunoglobulin G Langerhans Cells Immunology Tumor necrosis factor alpha Dermatologic Agents business |
| Popis: | Only limited data are available on the effects of TNF-alpha inhibitors on dendritic cells. However, TNF-alpha plays a central role in the biology of dendritic cells, both with regard to their maturity process and mobilization to secondary lymphoid organs. In particular, the effects of TNF-alpha inhibitors on Langerhans cells in healthy skin have never been investigated. In this pilot study, we aimed to assess the change of the density of Langerhans cells within the normal, not photo-exposed, skin of 17 psoriatic patients, before and after 16 weeks of treatment with TNF-alpha inhibitors. Most of the patients (88%) showed an increase or a similar density of Langerhans cells after 16 weeks of therapy with TNF-alpha inhibitors compared with baseline values. Only 2 patients (12%) showed a reduction of these cells following therapy with TNF-alpha inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|