Assessment of iron overload in very young children with limited thalassemia care resources in South China

Autor:	Darshana D. Rasalkar, Winnie C.W. Chu, Jian Pei Fang, Hong-Ying Gao, Chun Fu Li, Xin-Hua Zhang, Xin Sun, Fernando Tricta, Wen Ge Hao, Guang Fu Chen, Min Deng, Sio Peng A. Mok, Wing-Yan Au, Chang Gang Li, Xue Dong Wu
Rok vydání:	2014
Předmět:	Adult Male Pediatrics medicine.medical_specialty China South china Hemosiderosis Iron Overload Adolescent Heart Diseases Quality Assurance Health Care Thalassemia Clinical Biochemistry Population Young Adult Assessment data medicine Liver iron Humans education Child Serum ferritin Genetics (clinical) education.field_of_study medicine.diagnostic_test business.industry Biochemistry (medical) beta-Thalassemia Magnetic resonance imaging Hematology medicine.disease Magnetic Resonance Imaging Ferritins business Needs Assessment
Zdroj:	Hemoglobin. 38(2)
ISSN:	1532-432X
Popis:	Southern China has one of the world's largest population of patients needing transfusions. Transfusion and chelation are not uniformly available and no magnetic resonance imaging (MRI) assessment data exists to date. A total of 153 young β-thalassemia major (β-TM) patients were assessed using a validated 1.5T scanner in Hong Kong, People's Republic of China (PRC). Their median age was 13 (range 7 to 30), and most patients were young (22.0% age10, 73.0% age15, 88.0% age18). Erratic health care made estimation of total transfusion and chelation exposure impossible. Despite their early age, 24.0% had severe cardiac hemosiderosis [T2*10 milliseconds (ms)], at ages as early as 8 years old. Median heart iron was 1.68 mg/g dry weight (range 0.19-7.66) and increased with age (p = 0.017), while liver iron was 22.2 mg/g dry weight (range 3.15 to 39.2). Serum ferritin levels were poor predictors of heart and liver, or pancreatic R* and pituitary R* values. Magnetic resonance imaging scans are needed to screen very young β-TM patients with immediate risk of premature cardiac death in developing nations and triage them to more intensive treatment. This is particularly important in countries with a large number of patients and limited resources. Our data suggests that in developing countries, there is no lower limit for thalassemia MRI scanning programs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25279f5b46103efbab32c06e0c3dfb23 https://pubmed.ncbi.nlm.nih.gov/24502375 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.