Subgenual cingulate and visual cortex responses to sad faces predict clinical outcome during antidepressant treatment for depression☆

Autor: Paul Anthony Keedwell, D. Drapier, Mick Brammer, Simon Surguladze, Vincent Giampietro, Mary L. Phillips
Přispěvatelé: Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Service de Psychiatrie de l'adulte [Rennes], Centre Hospitalier Guillaume Régnier-Université européenne de Bretagne - European University of Brittany (UEB)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institute of Psychiatry, King's College London, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-Centre Hospitalier Guillaume Régnier
Rok vydání: 2010
Předmět:
Zdroj: Journal of Affective Disorders
Journal of Affective Disorders, Elsevier, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
Journal of Affective Disorders, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
ISSN: 0165-0327
1573-2517
DOI: 10.1016/j.jad.2009.04.031
Popis: Background Previous follow-up studies indicate that increased visual cortical, ventral cingulate and subcortical responses of depressed individuals to sad facial stimuli, but not happy stimuli could represent reversible markers of disease severity. We hypothesized that greater responses in these areas to sad stimuli, but not happy stimuli, would predict better subsequent clinical outcome. We also explored areas that would predict a poor outcome. Methods Twelve melancholically depressed individuals in the early stages of antidepressant treatment in a secondary care setting participated in two experiments comparing responses to varying intensities of sad and happy facial stimuli, respectively, using event related functional MRI. They repeated the experiments after a mean delay of 12 weeks of treatment. Results There was a variation in response to treatment. Greater right visual cortex and right subgenual cingulate (R-BA25) responses to sad stimuli, but not happy stimuli, in the early stages of treatment were associated with a good clinical outcome. Greater ventrolateral prefrontal cortex responses to either stimulus type were associated with a relatively poor outcome. Limitations The sample size was modest and patients were taking a variety of antidepressants. Conclusions Right subgenual cingulate and right visual cortical responses to sad stimuli predict good clinical outcome in the context of antidepressant treatment for severe depression in a naturalistic setting. Ventrolateral prefrontal cortex activity may indicate poor prognosis due to its relationship with negative rumination.
Databáze: OpenAIRE
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