The effects of cinanserin, a potent serotonin antagonist, on the acquisition of a running response in the rat
| Autor: | A.J. Rosen, M.E. Cohen |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Sulfides Pharmacology Placebo Cellular and Molecular Neuroscience Internal medicine medicine Animals Anilides Serotonin Antagonists Saline Dose-Response Relationship Drug business.industry Performance impairment Antagonist Rats Cinanserin Dose–response relationship Endocrinology Cinnamates Conditioning Operant Serotonin business |
| Zdroj: | Neuropharmacology. 12:501-508 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(73)90001-4 |
| Popis: | Three groups of hungry rats ( n = 15) were given either saline placebo injections or injections of a potent serotonin antagonist (Cinanserin; 12 or 36 mg/kg i.p.) and given 45 training trials in a straight alley for food reward. Thirty additional testing trials followed in which subjects were run under the same injection conditions as in training or under either of the alternative injection conditions. The high drug dosage caused a significant performance impairment but the effects did not persist into the testing phase when the subjects were taken off the high dose injection. In addition, high drug dosage subjects consistently initiated the day's responding at a lower level than the previous experimental day's terminal performance asymptote. These results are discussed in terms of the putative involvement of serotonin in the observed behavioral modifications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|