Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study
| Autor: | Basaran, Ozcan, Dogan, Volkan, Beton, Osman, Tekinalp, Mehmet, Aykan, Ahmet Cagri, Kalaycioglu, Ezgi, Bolat, Ismail, Tasar, Onur, Safak, Ozgen, Kalcik, Macit, Yaman, Mehmet, Inci, Sinan, Altintas, Bernas, Kalkan, Sedat, Kirma, Cevat, Biteker, Murat, Karadeniz, Fatma Ozpamuk, Tekkesin, Ahmet Ilker, Cakilli, Yasin, Turkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gursoy, Mustafa Ozan, Ozturk, Mujgan Tek, Aksan, Gokhan, Seyis, Sabri, Balli, Mehmet, Alici, Mehmet Hayri, Bozyel, Serdar, Altun, Ibrahim, Calik, Feyza, Karaca, Oguz, Helvaci, Fusun, Akay, Kadriye, Canga, Yigit, Celebi, Savas, Altuntas, Emine, Ayturk, Mehmet, Gunes, Haci Murat, Bezgin, Tahir, Aksakal, Aytekin, Cakal, Beytullah, Colak, Ayse, Kaplan, Ozgur, Tatlisu, Adem, Gozubuyuk, Gokhan, Demirelli, Selami, Kaya, Adnan, Rencuzogullari, Ibrahim, Bayram, Zubeyde, Simsek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, Ali Ekber, Gol, Gokhan, Mert, Gurbet Ozge, Mert, Kadir Ugur, Degirmencioglu, Aleks, Candan, Ozkan, Celebi, Ozlem Ozcan, Dogan, Cem, Yavuz, Fethi, Ulucan, Seref, Arisoy, Arif, Sahin, Bingul Dilekci, Ermis, Emrah, Gokaslan, Serkan, Pektas, Idris, Tanindi, Asli, Tekin, Kamuran, Sancar, Kadriye Memic, Cekic, Edip Guvenc, Basaran, Nesrin Filiz |
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| Přispěvatelé: | Acibadem University Dspace, Basaran, Ö., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey -- Dogan, V., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey -- Beton, O., Department of Cardiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey -- Tekinalp, M., Department of Cardiology, Kahramanmaras Necip Fazl State Hospital, Kahramanmaras, Turkey -- Aykan, A.C., Department of Cardiology, Trabzon Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey -- Kalaycioglu, E., Department of Cardiology, Trabzon Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey -- Bolat, I., Department of Cardiology, Fethiye State Hospital, Fethiye, Turkey -- Tasar, O., Department of Cardiology, Elazg Education and Research Hospital, Elazg, Turkey -- Safak, Ö., Department of Cardiology, Burdur State Hospital, Burdur, Turkey -- Kalcik, M., Department of Cardiology, Skilip Atf Hoca State Hospital, Corum, Turkey -- Yaman, M., Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey -- Nci, S., Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey -- Altintas, B., Department of Cardiology, Diyarbakr Gazi Yasargil Education and Research Hospital, Diyarbakr, Turkey -- Kalkan, S., Department of Cardiology, Gönen State Hospital, Gönen, Turkey -- Kirma, C., Kartal Kosuyolu Heart Education and Research Hospital, Kartal, Istanbul, Turkey -- Biteker, M., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, [Karadeniz, Fatma Ozpamuk] Sanliurfa Balikligol State Hosp, Dept Cardiol, Merkez Sanliurfa, Turkey -- [Tekkesin, Ahmet Ilker -- Turkkan, Ceyhan -- Cakal, Beytullah] Siyami Ersek Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Cakilli, Yasin] Tuzla State Hosp, Dept Cardiol, Tuzla Istanbul, Turkey -- [Hamidi, Mehmet] Bandirma State Hosp, Dept Cardiol, Balikesir, Turkey -- [Demir, Vahit] Yozgat State Hosp, Dept Cardiol, Yozgat, Turkey -- [Gursoy, Mustafa Ozan] Gaziemir State Hosp, Dept Cardiol, Gaziemir, Turkey -- [Ozturk, Mujgan Tek -- Ayturk, Mehmet] Ankara Kecioren Educ & Res Hosp, Dept Cardiol, Ankara, Turkey -- [Aksan, Gokhan -- Helvaci, Fusun] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Cardiol, Sisli, Turkey -- [Seyis, Sabri] Mersin Private Dogus Hosp, Dept Cardiol, Mersin, Turkey -- [Balli, Mehmet] Mersin Toros State Hosp, Dept Cardiol, Mersin, Turkey -- [Alici, Mehmet Hayri] Gaziantep 25 Aralik State Hosp, Dept Cardiol, Gaziantep, Turkey -- [Bozyel, Serdar] Kocaeli Derince Educ & Res Hosp, Dept Cardiol, Kocaeli, Turkey -- [Altun, Ibrahim -- Mert, Gurbet Ozge -- Mert, Kadir Ugur -- Sancar, Kadriye Memic] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Calik, Feyza] Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- [Karaca, Oguz -- Gunes, Haci Murat] Istanbul Medipol Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Akay, Kadriye] Kocaeli State Hosp, Dept Cardiol, Kocaeli, Turkey -- [Canga, Yigit -- Bayram, Zubeyde -- Simsek, Zeki] Kartal Yavuz Selim State Hosp, Dept Cardiol, Istanbul, Turkey -- [Celebi, Savas] TOBB ETU Hosp, Dept Cardiol, Ankara, Turkey -- [Altuntas, Emine] Bingol State Hosp, Dept Cardiol, Bingol, Turkey -- [Bezgin, Tahir] Gebze Fatih State Hosp, Dept Cardiol, Gebze, Turkey -- [Aksakal, Aytekin] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Colak, Ayse] Mut State Hosp, Dept Cardiol, Mersin, Turkey -- [Kaplan, Ozgur -- Gozubuyuk, Gokhan -- Dogan, Cem] Malatya State Hosp, Dept Cardiol, Malatya, Turkey -- [Tatlisu, Adem] Sivas Numune State Hosp, Dept Cardiol, Sivas, Turkey -- [Demirelli, Selami -- Sahin, Bingul Dilekci -- Ermis, Emrah] Erzurum Bolge Educ & Res Hosp, Dept Cardiol, Erzurum, Turkey -- [Kaya, Adnan] Suruc State Hosp, Dept Cardiol, Sanliurfa, Turkey -- [Rencuzogullari, Ibrahim] Kafkas Univ, Fac Med, Dept Cardiol, Kars, Turkey -- [Civan, Murat] Istanbul Private Liv Hosp, Dept Cardiol, Istanbul, Turkey -- [Batgharel, Ulaankhu] Acibadem Private Hosp, Dept Cardiol, Istanbul, Turkey -- [Ata, Ali Ekber] Samsun Medikal Pk Hosp, Dept Cardiol, Samsun, Turkey -- [Gol, Gokhan] Sureyyapasa Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Degirmencioglu, Aleks] Istanbul Acibadem Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Candan, Ozkan] Usak State Hosp, Dept Cardiol, Usak, Turkey -- [Celebi, Ozlem Ozcan] Private Medicana Int Ankara Hosp, Dept Cardiol, Ankara, Turkey -- [Yavuz, Fethi] Dr Ersin Arslan State Hosp, Dept Cardiol, Gaziantep, Turkey -- [Ulucan, Seref] Mevlana Univ, Fac Med, Dept Cardiol, Konya, Turkey -- [Arisoy, Arif] Gaziosmanpasa Univ, Fac Med, Dept Cardiol, Gaziosmanpasa, Turkey -- [Gokaslan, Serkan] Istanbul Haydarpasa Numune Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Pektas, Idris] Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey -- [Tanindi, Asli] Ufuk Univ, Fac Med, Dept Cardiol, Ufuk, Turkey -- [Tekin, Kamuran] Batman Bolge State Hosp, Dept Cardiol, Batman, Turkey -- [Cekic, Edip Guvenc -- Basaran, Nesrin Filiz] Mugla Sitki Kocman Univ, Fac Med, Dept Pharmacol, Mugla, Turkey -- [Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Fethiye, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Inci, Sinan] Aksaray State Hosp, Dept Cardiol, Aksaray, Turkey -- [Altintas, Bernas] Diyarbakir Gazi Yasargil Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey -- [Kalkan, Sedat] Gonen State Hosp, Dept Cardiol, Gonen, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, BASARAN, OZCAN -- 0000-0002-6384-6455 |
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
Vitamin K Turkey Undertreatment Administration Oral 030204 cardiovascular system & hematology 0302 clinical medicine Risk Factors Atrial Fibrillation atrial fibrillation off-label use 030212 general & internal medicine Prospective Studies Registries Prospective cohort study anticoagulation Stroke Over-Treatment General Medicine Vitamin K antagonist stroke ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Practice Guidelines as Topic Guideline Adherence InformationSystems_MISCELLANEOUS medicine.drug Research Article medicine.medical_specialty medicine.drug_class Renal function Observational Study Subgroup analysis Hemorrhage Dabigatran 03 medical and health sciences Anticoagulation medicine Humans Rivaroxaban undertreatment business.industry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Anticoagulants Guideline Off-Label Use medicine.disease Cross-Sectional Studies ComputingMethodologies_PATTERNRECOGNITION over-treatment business |
| Zdroj: | Medicine |
| Popis: | WOS: 000384041400052 PubMed ID: 27583892 This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of |
| Databáze: | OpenAIRE |
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