10 kHz SCS therapy for chronic pain, effects on opioid usage: Post hoc analysis of data from two prospective studies
| Autor: | Roy Carganillo, Bradford E. Gliner, Catherine Panwar, Jean-Pierre Van Buyten, Anand Rotte, Adnan Al-Kaisy, David Caraway, Kasra Amirdelfan, Leonardo Kapural, Jeyakumar Subbaroyan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Visual analogue scale lcsh:Medicine Drug Prescriptions Article 03 medical and health sciences 0302 clinical medicine Quality of life Post-hoc analysis Medicine Humans Pain Management Patient Reported Outcome Measures Prospective Studies lcsh:Science Adverse effect Prospective cohort study Aged Pain Measurement Spinal Cord Stimulation Multidisciplinary business.industry lcsh:R Chronic pain Health care Middle Aged medicine.disease Drug Utilization Analgesics Opioid 030104 developmental biology Treatment Outcome Opioid Neurology Anesthesia Morphine Quality of Life Feasibility Studies lcsh:Q Female Chronic Pain business Low Back Pain 030217 neurology & neurosurgery medicine.drug Follow-Up Studies |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Chronic pain, including chronic low back and leg pain are prominent causes of disability worldwide. While patient management aims to reduce pain and improve daily function, prescription of opioids remains widespread despite significant adverse effects. This study pooled data from two large prospective trials on 10 kHz spinal cord stimulation (10 kHz SCS) in subjects with chronic low back pain and/or leg pain and performed post hoc analysis on changes in opioid dosage 12 months post 10 kHz SCS treatment. Patient-reported back and leg pain using the visual analog scale (VAS) and opioid dose (milligrams morphine equivalent/day, MME/day) were compared at 12 months post-10 kHz SCS therapy to baseline. Results showed that in the combined dataset, 39.3% of subjects were taking >90 MME dose of opioids at baseline compared to 23.0% at 12 months post-10 kHz SCS therapy (p = 0.007). The average dose of opioids in >90 MME group was significantly reduced by 46% following 10 kHz SCS therapy (p |
| Databáze: | OpenAIRE |
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