Prevalence and Prognostic Significance of Right Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy
| Autor: | Yong Yang, Xiao Bo Pu, Shi-Jian Chen, Jageshwar Prasad Shah, Mao Chen, Yucheng Chen, Yuanweixiang Ou, Tian-li Xia, Abdullah Hagar |
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| Rok vydání: | 2018 |
| Předmět: |
Male
China medicine.medical_specialty Systole Heart Ventricles Ventricular Dysfunction Right Cardiomyopathy Magnetic Resonance Imaging Cine 030204 cardiovascular system & hematology Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Prevalence medicine Humans Clinical significance In patient Retrospective Studies Ejection fraction medicine.diagnostic_test business.industry Hypertrophic cardiomyopathy Stroke Volume Magnetic resonance imaging Retrospective cohort study Cardiomyopathy Hypertrophic Middle Aged Prognosis medicine.disease Ventricular Function Right Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 122:1932-1938 |
| ISSN: | 0002-9149 |
| Popis: | Few data are available regarding the prevalence and clinical significance of right ventricular systolic dysfunction (RVSD) in hypertrophic cardiomyopathy (HC) patients. This study aimed to evaluate right ventricular (RV) systolic function by cardiovascular magnetic resonance and explore the prevalence and prognostic significance of RVSD in HC patients. A total of 226 patients with HC assessed by cardiovascular magnetic resonance were included in this retrospective study. RVSD was defined by RV ejection fraction (RVEF) ≤45% and was present in 26 (11.5%) patients. Association between RVSD, clinical characteristics, and outcomes were analyzed. RVEF was significantly lower in patients with RVSD than without RVSD (36.2 ± 7.0% vs 60.5 ± 7.4%, p0.001). There was a positive correlation between RVEF and left ventricular ejection fraction (r = 0.45; p0.001). During a mean follow-up of 30.5 ± 23.9 months, there were 22 (9.7 %) all-cause mortality, including 12 (5.3%) cardiovascular death. Kaplan-Meier analysis showed a significantly higher risk for cardiovascular mortality in patients with RVSD (p = 0.026), but no significant difference in all-cause mortality (p = 0.118) and heart failure related rehospitalization (p = 0.485). On multivariate Cox regression analysis, RVSD (hazard ratio 5.36; confidence interval 1.39 to 20.77; p = 0.015) and RVEF (hazard ratio 0.94; confidence interval 0.89 to 0.98; p = 0.011) were independent predictors of cardiovascular mortality. In conclusion, RVSD is a common phenotype and a strong independent predictor of cardiovascular mortality in HC patients. |
| Databáze: | OpenAIRE |
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