| Autor: |
Timothy Neubert, Timothy Coon, Brett B. Busch, Justin T. Ernst, Paul Krenitsky, Leonard Kaljevic, Edwin Schweiger, Andreas Termin, Jeremy J. Clemens, Dean Stamos, Juliana L. Asgian |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
The Journal of organic chemistry. 78(2) |
| ISSN: |
1520-6904 |
| Popis: |
Efforts to substitute the cyclopropane ring in a series of aryl cyclopropylnitriles led to the discovery of an operationally simple one-pot method for Knoevenagel condensation and subsequent Corey-Chaykovsky cyclopropanation giving diastereomerically pure products as a racemic mixture of enantiomers. Method development and results for variably substituted aryl acetonitriles and aldehydes in the reaction are reported. A concise synthesis of (±)-bicifadine in two steps is provided to demonstrate the utility of the method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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