Robust and Responsive Silk Ionomer Microcapsules
| Autor: | Chunhong Ye, Rossella Calabrese, Olga Shchepelina, Vladimir V. Tsukruk, Irina Drachuk, David L. Kaplan |
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| Rok vydání: | 2011 |
| Předmět: |
Polymers and Plastics
Surface Properties Fibroin Biocompatible Materials Capsules Bioengineering Article Biomaterials chemistry.chemical_compound Polymer chemistry Materials Chemistry medicine Polylysine Ionomer fungi Hydrogen-Ion Concentration Polyelectrolyte SILK Polyglutamic Acid chemistry Chemical engineering Permeability (electromagnetism) Swelling medicine.symptom Fibroins Macromolecule |
| Zdroj: | Biomacromolecules. 12:4319-4325 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/bm201246f |
| Popis: | We demonstrate the assembly of extremely robust and pH-responsive thin shell LbL microcapsules from silk fibroin counterparts modified with poly(lysine) and poly(glutamic) acid, which are based on biocompatible silk ionomer materials in contrast with usually exploited synthetic polyelectrolytes. The microcapsules are extremely stable in an unusually wide pH range from 1.5 to 12.0 and show a remarkable degree of reversible swelling/deswelling response in dimensions, as exposed to extreme acidic and basic conditions. These changes are accompanied by reversible variations in shell permeability that can be utilized for pH-controlled loading and unloading of large macromolecules. Finally, we confirmed that these shells can be utilized to encapsulate yeast cells with a viability rate much higher than that for traditional synthetic polyelectrolytes. |
| Databáze: | OpenAIRE |
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