Association between myocardial hypoxia and fibrosis in hypertrophic cardiomyopathy: analysis by T2* BOLD and T1 mapping MRI
| Autor: | Akiko Sakai, Risako Nakao, Kiyoe Ando, Michinobu Nagao, Umiko Ishizaki, Nobuhisa Hagiwara, Eri Watanabe, Shuji Sakai, Atsushi Suzuki |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Myocardial Ischemia Contrast Media Magnetic Resonance Imaging Cine Gadolinium 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fibrosis Cardiac magnetic resonance imaging Predictive Value of Tests Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Hypoxia Aged medicine.diagnostic_test Inhalation business.industry Myocardium Hypertrophic cardiomyopathy Heart General Medicine Odds ratio Hypoxia (medical) Cardiomyopathy Hypertrophic Middle Aged medicine.disease Magnetic Resonance Imaging Confidence interval Oxygen ROC Curve 030220 oncology & carcinogenesis Cardiology Myocardial fibrosis Female Radiology medicine.symptom business |
| Zdroj: | European radiology. 30(8) |
| ISSN: | 1432-1084 |
| Popis: | We assessed whether an association exists between myocardial oxygenation and myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM), using blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR) and T1 mapping. T1 mapping and T2*-CMR data were collected from 55 HCM patients using a 3-T MR and were prospectively analyzed. T2*-CMR was conducted using the black blood, breath-hold, multi-echo, and gradient echo sequence. Over 10 min, inhalation of oxygen at the flow rate of 10 L/min, T2* for mid-septum was measured following room-air and oxygen inhalation, and ΔT2* ratio (T2*oxy-T2*air/T2*air, %) was calculated. During pre- and post-gadolinium enhancement, native T1 (ms) and extracellular volume fractions (ECV, %) were calculated at sites same as the T2* measurement. Hypoxia was defined as the segment with an absolute value of the ΔT2* ratio ≥ 10%. ΔT2* ratio was significantly higher for segments with native T1 ≥ 1290 ms than those with native T1 |
| Databáze: | OpenAIRE |
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