Environment dominates over host genetics in shaping human gut microbiota
| Autor: | Noam Bar, Paul I. Costea, Tal Korem, Gal Malka, Jingyuan Fu, Arnau Vich Vila, Elad Barkan, Anastasia Godneva, Tali Avnit-Sagi, Iris N. Kalka, Omer Weissbrod, Cisca Wijmenga, Eran Segal, Bat Chen Wolf, Alexandra Zhernakova, Niv Zmora, Adina Weinberger, Eran Elinav, Shai Carmi, Dar Lador, Maya Lotan-Pompan, Smadar Shilo, David Israeli, Zamir Halpern, David Zeevi, Noa Kosower, Alexander Kurilshikov, Meirav Pevsner-Fischer, Daphna Rothschild |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Department of Health and Life Sciences, Translational Immunology Groningen (TRIGR), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Heredity PREDICTION Twins DIVERSITY Genome-wide association study METAGENOMICS Cohort Studies RNA Ribosomal 16S Genotype Israel Gene–environment interaction Aged 80 and over Genetics PROPORTION Family Characteristics Multidisciplinary HERITABILITY Middle Aged Healthy Volunteers RNA Bacterial Phenotype Twin Studies as Topic Female Adult Adolescent Genetic genealogy Environment Biology Polymorphism Single Nucleotide Bacterial genetics LINEAR MIXED MODELS Young Adult 03 medical and health sciences RELATEDNESS Humans Obesity Microbiome GENOME-WIDE ASSOCIATION Life Style Aged Reproducibility of Results Heritability FRAMEWORK Diet Gastrointestinal Microbiome Glucose 030104 developmental biology Metagenomics Gene-Environment Interaction INFERENCE |
| Zdroj: | Nature, 555(7695), 210-228. Nature Publishing Group Nature |
| ISSN: | 0028-0836 |
| Popis: | Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds. |
| Databáze: | OpenAIRE |
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