Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment
| Autor: | Andrea Falini, Isabella Castiglioni, Laura Parisi, Antonella Iadanza, Stefano F. Cappa, Eleonora Catricalà, Antonio G. Zippo, Virginia M. Borsa, Pasquale Anthony Della Rosa |
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| Přispěvatelé: | Catricalà, E, Della Rosa, Pa, Parisi, L, Zippo, Ag, Borsa, Vm, Iadanza, A, Castiglioni, I, Falini, Andrea, Cappa, Sf, Della Rosa, P, Zippo, A, Borsa, V, Falini, A, Cappa, S |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cognitive Neuroscience Graph analysis Experimental and Cognitive Psychology Picture naming Left fusiform gyrus behavioral disciplines and activities Amnestic Mild Cognitive Impairment fMRI Behavioral Neuroscience Functional connectivity mental disorders Semantic memory Humans Cognitive Dysfunction Cognitive impairment Aged Word reading Brain Mapping Fusiform gyrus Semantic context effect Living-nonliving Brain Middle Aged Magnetic Resonance Imaging Semantics Increased risk Pattern Recognition Visual Reading Homogeneous Mental Recall Female Amnesia Psychology Cognitive psychology MRI |
| Zdroj: | Neuropsychologia 76 (2015): 136–152. doi:10.1016/j.neuropsychologia.2015.01.009 info:cnr-pdr/source/autori:Catricala E.; Della Rosa P.A.; Parisi L.; Zippo A.G.; Borsa V.M.; Iadanza A.; Castiglioni I.; Falini A.; Cappa S.F./titolo:Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment/doi:10.1016%2Fj.neuropsychologia.2015.01.009/rivista:Neuropsychologia (Print)/anno:2015/pagina_da:136/pagina_a:152/intervallo_pagine:136–152/volume:76 |
| Popis: | Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology. |
| Databáze: | OpenAIRE |
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