Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population
| Autor: | Andrzej Szczudlik, Joanna Pera, Anna Dziubek, Tomasz Dziedzic, Aleksandra Klimkowicz-Mrowiec, Agnieszka Slowik, Małgorzata Sado |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Apolipoprotein E Complement receptor 1 CLU Single-nucleotide polymorphism Polymorphism Single Nucleotide White People PICALM single nucleotide polymorphism Alzheimer Disease Polymorphism (computer science) Humans SNP Medicine CR1 Aged Genetic association Genetics choroba Alzheimera Clusterin biology business.industry polimorfizm pojedynczego nukleotydu Monomeric Clathrin Assembly Proteins biology.protein Female Surgery Poland Neurology (clinical) Alzheimer disease biology.gene business Genome-Wide Association Study |
| Popis: | Background and purpose Recent genome-wide association studies have indicated 3 new susceptibility loci for Alzheimer disease (AD): complement receptor 1 (CR1), clusterin (CLU), and the phosphatidylinositol-binding clathrin assembly protein (PICALM). We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population. Material and methods In 253 Caucasian AD patients and 240 controls, analyses identifying the rs6656401, rs3851179 and rs11136000 SNPs and APOE common polymorphisms were performed. Results No significant differences were observed in the distribution of the rs6656401 of CR1, rs3851179 of PICALM and rs11136000 of CLU SNPs between AD patients and controls. The APOE ɛ4 common polymorphism was strongly related to the risk of AD. Conclusion Our results suggest that investigated SNPs are not associated with AD in a Polish population. |
| Databáze: | OpenAIRE |
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