Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate
| Autor: | A J Taylor, C M Luczynska, R Hawkins, W. Howe, M. D. Topping, Katherine M. Venables |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Hypersensitivity Immediate Male Population Serum albumin Phthalic Acids Immunoglobulin E Antibodies Atopy Medicine Humans education Serum Albumin General Environmental Science Asthma Skin Tests education.field_of_study biology medicine.diagnostic_test business.industry Radioallergosorbent test Smoking General Engineering General Medicine medicine.disease Occupational Diseases body regions Phthalic Anhydrides Immunology biology.protein General Earth and Planetary Sciences Female Antibody Electronics business Hapten Haptens Research Article |
| Popis: | A survey was carried out of a population of workers exposed to tetrachlorophthalic anhydride, an acid anhydride epoxy resin curing agent known to cause asthma. Using a radioallergosorbent test with a tetrachlorophthalic anhydride human serum albumin conjugate, specific IgE antibody was detected in serum from 24 out of 300 factory floor workers exposed to tetrachlorophthalic anhydride. Of these 24, 20 (83.3%) were current smokers compared with 133 (48.2%) of 276 without antibody (p less than 0.01), and there was a weaker association with atopy, defined by skin tests with common allergens. Smoking and atopy interacted, the prevalence of antibody being 16.1% in atopic smokers, 11.7% in non-atopic smokers, 8.3% in atopic non-smokers, and nil in non-atopic non-smokers (p less than 0.025). Smoking may predispose to, and interact with atopy in, the production of specific IgE antibody to this hapten protein conjugate. |
| Databáze: | OpenAIRE |
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