Improved outcomes with a standardized feeding protocol for very low birth weight infants
| Autor: | Ronald S. Cohen, K. R. McCallie, Susan R. Hintz, Henry C. Lee, O Mayer, William D. Rhine |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Food
Formulated Percentile Pediatrics medicine.medical_specialty business.industry Infant Newborn Obstetrics and Gynecology Enteral feedings medicine.disease Enteral administration Sepsis Low birth weight Primary outcome Parenteral nutrition Enteral Nutrition Infant Extremely Low Birth Weight Pediatrics Perinatology and Child Health Necrotizing enterocolitis medicine Humans Infant Very Low Birth Weight Parenteral Nutrition Total medicine.symptom business Infant Nutritional Physiological Phenomena |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association. 31 |
| ISSN: | 1476-5543 |
| Popis: | The objective of this study was to evaluate the impact of a standardized enteral feeding protocol for very low birth weight (VLBW) infants on nutritional, clinical and growth outcomes. Retrospective analysis of VLBW cohorts 9 months before and after initiation of a standardized feeding protocol consisting of 6–8 days of trophic feedings, followed by an increase of 20 ml/kg/day. The primary outcome was days to reach full enteral feeds defined as 160 ml/kg/day. Secondary outcomes included rates of necrotizing enterocolitis and culture-proven sepsis, days of parenteral nutrition and growth end points. Data were analyzed on 147 VLBW infants who received enteral feedings, 83 before (‘Before’) and 64 subsequent to (‘After’) feeding protocol initiation. Extremely low birth weight (ELBW) infants in the After group attained enteral volumes of 120 ml/kg/day (43.9 days Before vs 32.8 days After, P=0.02) and 160 ml/kg/day (48.5 days Before vs 35.8 days After, P=0.02) significantly faster and received significantly fewer days of parenteral nutrition (46.2 days Before vs 31.3 days After, P=0.01). Necrotizing enterocolitis decreased in the After group among VLBW (15/83, 18% Before vs 2/64, 3% After, P=0.005) and ELBW infants (11/31, 35% Before vs 2/26, 8% After, P=0.01). Late-onset sepsis decreased significantly in the After group (26/83, 31% Before vs 6/64, 9% After, P=0.001). Excluding those with weight |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|