Medicinal Foodstuffs. XVIII. Phytoestrogens from the Aerial Part of Petroselinum crispum MILL. (PARSLEY) and Structures of 6'-Acetylapiin and a New Monoterpene Glycoside, Petroside
| Autor: | Akinobu Kishi, Yuzo Kawahara, Masayuki Yoshikawa, Toshiaki Uemura, Hiroshi Shimoda, Hisashi Matsuda |
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| Rok vydání: | 2000 |
| Předmět: |
Ovariectomy
Phytoestrogens Mice chemistry.chemical_compound Drug Discovery Animals Humans Estrogens Non-Steroidal Apigenin Flavonoids chemistry.chemical_classification Plants Medicinal Traditional medicine Terpenes Methanol Uterus Daidzein Glycoside General Chemistry General Medicine Isoflavones Apiin Diosmetin chemistry Biochemistry Female Plant Preparations Kaempferol Apiaceae |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 48:1039-1044 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.48.1039 |
| Popis: | In the course of our screening for natural estrogenic compounds from Occidental medicinal herbs, the extracts of several herbs were found to show proliferative activity in MCF-7 (an estrogen-sensitive breast cancer cell line). Among these active herbs, the methanolic extract from the aerial parts of Petroselinum crispum (parsley) showed potent estrogenic activity, which was equal to that of isoflavone glycosides from soybean. Through bioassay-guided separation, we isolated several flavone glycosides and a new flavone glycoside, 6"-acetylapiin, with estrogenic activity together with a new monoterpene glucoside, petroside. The structures of 6"-acetylapiin and petroside were characterized by the chemical and physicochemical evidence. Estrogenic activities of these flavone glycosides were found to be enhanced by removal of their glycoside moieties. The EC50 values (concentration needed to enhance the MCF-7 proliferation 50% compared to non-estrogen treated cell) of their aglycones are as follows, apigenin (1.0 microM), diosmetin (2.9 microM), and kaempferol (0.56 microM). The estrogenic activities of these flavones are nearly equal to those of the isoflavones, daidzein (0.61 microM) and genistein (0.60 microM). The methanolic extract of parsley, apiin, and apigenin restored the uterus weight in ovariectomized mice when orally administered for consecutive 7 days. |
| Databáze: | OpenAIRE |
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