Update on pediatric testicular germ cell tumors
| Autor: | Elisabeth T. Tracy, David A. Rodeberg, Jennifer H. Aldrink, Erin G. Brown, Peter F. Ehrlich, Timothy B. Lautz, Reto M. Baertschiger, Richard D. Glick, Peter Mattei, Afif N. Kulaylat, David H. Rothstein, Christa N. Grant, Roshni Dasgupta, Emily R. Christison-Lagay |
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| Rok vydání: | 2022 |
| Předmět: |
Male
endocrine system Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment 03 medical and health sciences Retroperitoneal lymph node dissection 0302 clinical medicine Testicular Neoplasms 030225 pediatrics medicine Humans Prospective Studies Orchiectomy Child Neoplasm Staging business.industry Cancer Pediatric Surgeon General Medicine Evidence-based medicine Neoplasms Germ Cell and Embryonal medicine.disease Testicular germ cell Review article Clinical trial 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Lymph Node Excision Surgery business |
| Zdroj: | Journal of Pediatric Surgery. 57:690-699 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2021.04.001 |
| Popis: | Background Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management. Method A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article. Results In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. A summary of recently completed clinical trials by pediatric oncology cooperative groups is provided, and best surgical practices are discussed. Conclusions Testicular germ cell tumors in children are rare tumors. International collaborations, data-sharing, and enrollment of patients at all stages and risk classifications into active clinical trials will enhance our knowledge of these rare tumors and most importantly improve outcomes of patients with testicular germ cell tumors. Level of evidence This is a review article of previously published and referenced level 1 and 2 studies, but also includes expert opinion level 5, represented by the American Pediatric Surgical Association Cancer Committee. |
| Databáze: | OpenAIRE |
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