Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging
| Autor: | Emma M. Tinney, Psyche Loui, Lauren B. Raine, Lucy V. Hiscox, Peyton L. Delgorio, Mary K. Kramer, Hillary Schwarb, Christopher R. Martens, Arthur F. Kramer, Charles H. Hillman, Curtis L. Johnson |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Neuropsychology and Physiological Psychology
mild cognitive impairment Developmental Neuroscience Neurology Endocrine and Autonomic Systems relational memory Cognitive Neuroscience General Neuroscience white matter integrity aging Experimental and Cognitive Psychology body mass index Biological Psychiatry |
| Zdroj: | TInney, E M, Loui, P, Raine, L B, Hiscox, L V, Delgorio, P L, Kramer, M K, Schwarb, H, Martens, C R, Kramer, A F, Hillman, C H & Johnson, C L 2023, ' Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging ', Psychophysiology . https://doi.org/10.1111/psyp.14306 |
| Popis: | Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p’s |
| Databáze: | OpenAIRE |
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