| Autor: |
Mlynarczyk, Coraline, Teater, Matt, Chin, Christopher R., Arulraj, Theinmozhi, Hoehn, Kenneth B., Bandyopadhyay, Arnab, Chen, Zhengming, Doane, Ashley S., Elemento, Olivier, Meyer-Hermann, Michael, Melnick, Ari |
| Rok vydání: |
2023 |
| DOI: |
10.5281/zenodo.7406381 |
| Popis: |
Codes used in the study. Abstract:Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, whereby germinal center B cells vigorously compete for limiting positive selection signals. We show that mutations affectingBTG1disrupt a critical immune “gate-keeper” mechanism that strictly limits B cell fitness during antibody affinity maturation. This converts germinal center B cells into “super-competitors” that rapidly outstrip their normal counterparts. This effect is conferred by a minute shift in MYC protein induction kinetics yet results in aggressive invasive lymphomas, which in humans link to dire clinical outcomes. Our findings reveal a delicate evolutionary trade-off between natural selection of B cells to provide immunity and dangerous features that recall the more competitive nature of unicellular organisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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