The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance
| Autor: | Fatma Yılmaz, Sedat Abusoglu, Çiğdem Yücel, Müjgan Ercan, Yusuf Bayrakceken, Aysen Caniklioglu, Mehmet Ozcan, Esra Fırat Oğuz, Canan Topcuoglu |
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| Přispěvatelé: | Selçuk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Bölümü, Abuşoğlu, Sedat |
| Rok vydání: | 2018 |
| Předmět: |
Mikrobiyoloji
medicine.medical_treatment Tıbbi Laboratuar Teknolojisi lcsh:Medicine Nörolojik Bilimler Yoğun Bakım HOMA-IR Transplantasyon insulin resistance Statistics Range (statistics) Medicine Anatomi ve Morfoloji Enfeksiyon Hastalıkları Patoloji Sağlık Bilimleri ve Hizmetleri Cerrahi Dermatoloji lcsh:R5-920 Alerji Hücre Biyolojisi Odyoloji ve Konuşma-Dil Patolojisi Kulak Tıbbi İnformatik Kadın Hastalıkları ve Doğum Onkoloji Periferik Damar Hastalıkları Psikiyatri Tıp Tropik Tıp Gastroenteroloji ve Hepatoloji Measurement uncertainty lcsh:Medicine (General) Romatoloji Biyoloji cut-off Temel Sağlık Hizmetleri Biyoteknoloji ve Uygulamalı Mikrobiyoloji Nükleer Tıp Kalp ve Kalp Damar Sistemi Burun Endokrinoloji ve Metabolizma Anestezi Biyofizik Radyoloji Klinik Nöroloji Tıbbi Görüntüleme Üroloji ve Nefroloji Solunum Sistemi Insulin resistance Acil Tıp Androloji Spor Bilimleri Halk ve Çevre Sağlığı Genel ve Dahili Tıp Geriatri ve Gerontoloji Fizyoloji Göz Hastalıkları İmmünoloji Boğaz business.industry Insulin lcsh:R Tıbbi Araştırmalar Deneysel medicine.disease Tıbbi Etik Adli Tıp Pediatri Ortopedi Hematoloji Rehabilitasyon Tamamlayıcı ve Entegre Tıp Biyokimya ve Moleküler Biyoloji business |
| Zdroj: | Medicine Science, Vol 8, Iss 1, Pp 32-6 (2019) |
| ISSN: | 2147-0634 |
| Popis: | In this study, it is aimed to estimate not just the uncertainty measurement for the parameters of glucose and insulin having role when calculating HOMA-IR, but also true positiveness and negativeness in terms of cut-off values. The evaluation of the acceptability of the uncertainty value was also among the goals of the study. The uncertainty measurement for glucose and insulin is calculated as uncertainty measurement of HOMA-IR based on Eurochem/CITAC Guide CG 4. The uncertainty measurement for glucose and insulin was estimated as 3.83% and 4.16%, respectively. The measurement uncertainty for the calculated test HOMA-IR was calculated with cut-off values as 27% (0.27). Based on the cut-off value for HOMA-IR of 2.5%, IR(+) and IR(-) patients were 155 and 265, respectively. If the uncertainty measurement for HOMA-IR was added to its calculation, the cut-off value was detected as 2.23-2.77%. We reported the measurement uncertainty of the calculated test HOMA-IR at 95 % CI as 0.27 between 2.23 - 2.77. Especially for the tests used for screening; determination of cut-off values as a range including measurement uncertainty instead of a single value will be more suitable. No data is found in the literature for the calculated test HOMA-IR up to date. [Med-Science 2019; 8(1.000): 32-6] |
| Databáze: | OpenAIRE |
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