Serotype/serogroup-specific antibiotic non-susceptibility of invasive and non-invasive Streptococcus pneumoniae, Switzerland, 2004 to 2014

Autor: Aurélie Allemann, Christoph Hauser, Markus Hilty, Andreas Kronenberg, Kathrin Mühlemann
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Serotype
Epidemiology
Antibiotics
medicine.disease_cause
Disease Outbreaks
0302 clinical medicine
Risk Factors
Seroepidemiologic Studies
Prevalence
030212 general & internal medicine
Child
Aged
80 and over
Sulfamethoxazole
Middle Aged
Anti-Bacterial Agents
Streptococcus pneumoniae
Treatment Outcome
Child
Preschool
Female
Switzerland
medicine.drug
Adult
Adolescent
medicine.drug_class
030106 microbiology
Erythromycin
610 Medicine & health
Microbial Sensitivity Tests
Biology
Serogroup
Microbiology
Young Adult
03 medical and health sciences
Age Distribution
Antibiotic resistance
Virology
Drug Resistance
Bacterial
medicine
Humans
Sex Distribution
Aged
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
Pneumonia
Pneumococcal
Trimethoprim
Penicillin
570 Life sciences
biology
Zdroj: Hauser, Christoph; Kronenberg, Andreas; Allemann, Aurélie; Mühlemann, Kathrin; Hilty, Markus (2016). Serotype/serogroup-specific antibiotic non-susceptibility of invasive and non-invasive Streptococcus pneumoniae, Switzerland, 2004 to 2014. Euro surveillance, 21(21) Institut de Veille Sanitaire 10.2807/1560-7917.ES.2016.21.21.30239
ISSN: 1560-7917
DOI: 10.2807/1560-7917.es.2016.21.21.30239
Popis: Concurrent analysis of antibiotic resistance of colonising and invasive Streptococcus pneumoniae gives a more accurate picture than looking at either of them separately. Therefore, we analysed 2,129 non-invasive and 10,996 invasive pneumococcal isolates from Switzerland from 2004 to 2014, which spans the time before and after the introduction of the heptavalent (PCV7) and 13-valent (PCV13) conjugated pneumococcal polysaccharide vaccines. Serotype/serogroup information was linked with all antibiotic resistance profiles. During the study period, the proportion of non-susceptible non-invasive and invasive isolates significantly decreased for penicillin, ceftriaxone, erythromycin and trimethoprim/sulfamethoxazole (TMP-SMX). This was most apparent in non-invasive isolates from study subjects younger than five years (penicillin (p = 0.006), erythromycin (p = 0.01) and TMP-SMX (p = 0.002)). Resistant serotypes/serogroups included in PCV7 and/or PCV13 decreased and were replaced by non-PCV13 serotypes (6C and 15B/C). Serotype/serogroup-specific antibiotic resistance rates were comparable between invasive and non-invasive isolates. Adjusted odds ratios of serotype/serogroup-specific penicillin resistance were significantly higher in the west of Switzerland for serotype 6B (1.8; 95% confidence interval (CI): 1.4–4.8), 9V (3.4; 95% CI: 2.0–5.7), 14 (5.3; 95% CI: 3.8–7.5), 19A (2.2; 95% CI: 1.6–3.1) and 19F (3.1; 95% CI: 2.1–4.6), probably due to variations in the antibiotic consumption.
Databáze: OpenAIRE
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