Oral Probiotic Bifidobacterium Longum Supplementation Improves Metabolic Parameters and Alters the Expression of the Renin-Angiotensin System in Obese Mice Liver
| Autor: | Igor Viana Brandi, João Marcus Oliveira Andrade, Janaína Ribeiro Oliveira, Amanda Souto Machado, Sérgio Henrique Sousa Santos, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Deborah de Farias Lelis |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Bifidobacterium longum Tecido adiposo Sistema renina-angiotensina 030209 endocrinology & metabolism Disease Gut flora Diet High-Fat Proto-Oncogene Mas law.invention Renin-Angiotensin System 03 medical and health sciences Probiotic Mice 0302 clinical medicine law Non-alcoholic Fatty Liver Disease Internal medicine Renin–angiotensin system medicine Animals Obesity 030304 developmental biology Obese Mice 0303 health sciences Research and Theory biology business.industry Probiotics Fatty liver food and beverages biology.organism_classification medicine.disease Lipid Metabolism Endocrinology Obesidade Adipose Tissue Liver Dietary Supplements Fígado - Doenças business |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| ISSN: | 1552-4175 |
| Popis: | Background: Obesity and non-alcoholic fatty liver disease (NAFLD) have been increasing at an alarming rate worldwide. Bifidobacterium longum (BL), a common member of the human gut microbiota, has important health benefits through several mechanisms. Objectives: We evaluated the BL supplementation effects on body metabolism and renin-angiotensin components hepatic expression in mice fed a high-fat diet. Methods: Thirty-two male mice were divided into four groups: standard diet + placebo (ST), standard diet + Bifidobacterium longum (ST + BL), high-fat diet + placebo (HFD) and high-fat diet + Bifidobacterium longum (HFD + BL). Following the obesity induction period, the ST + BL and HFD + BL groups were supplemented with Bifidobacterium longum for 4 weeks. Then, body, biochemical, histological and molecular parameters were evaluated. Results: HFD + BL mice had a significant decrease in adipose tissue mass and blood glucose levels, as well as a significant reduction in blood glucose during an intraperitoneal glucose tolerance test. The treatment also resulted in reduced levels of total cholesterol and hepatic fat accumulation. Moreover, we observed an increase in angiotensin converting enzyme 2 (ACE2) and Mas receptor (MASR) expression levels in BL-treated obese mice. Conclusions: These data demonstrate that BL may have the potential to prevent obesity and NAFLD by modulating the mRNA expression of renin-angiotensin system components. |
| Databáze: | OpenAIRE |
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