Immunochemical fecal occult blood tests predict dual antiplatelet therapy discontinuation after coronary stenting
| Autor: | Yasunori Oguma, Toshimitsu Kosaka, Yutaka Terata, Kenji Iino, Takashi Koyama, Hiroshi Ito, Ken Ikeda, Megumi Okawa, Hiroyuki Watanabe, Masaru Ishida |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty animal structures Coronary Artery Disease Gastroenterology Coronary artery disease Coronary Restenosis Percutaneous Coronary Intervention Internal medicine Internal Medicine Medicine Humans In patient Stent thrombosis Aged Retrospective Studies Aged 80 and over business.industry Proportional hazards model Fecal occult blood Coronary stenting Reproducibility of Results Retrospective cohort study Drug-Eluting Stents General Medicine Middle Aged medicine.disease Immunohistochemistry Discontinuation Treatment Outcome Occult Blood Cardiology Female business Gastrointestinal Hemorrhage Platelet Aggregation Inhibitors Follow-Up Studies |
| Zdroj: | Internal medicine (Tokyo, Japan). 53(5) |
| ISSN: | 1349-7235 |
| Popis: | Objective The discontinuation of dual antiplatelet therapy (DAPT) increases the risk of stent thrombosis after coronary stenting. Some patients must discontinue DAPT due to gastrointestinal (GI) tract disease; however, the type of examination that is most useful for detecting GI tract diseases has not been fully evaluated. The purpose of this study was to clarify whether the immunochemical fecal occult blood test (iFOBT) can be used to predict GI tract disease-related DAPT discontinuation following stent implantation in patients with coronary artery disease. Methods A total of 181 consecutive DAPT-naive patients who underwent coronary stenting were divided into two groups according to the results of iFOBTs: a positive iFOBT group (n=32) and a negative iFOBT group (n=149). During the 12-month follow-up period, the DAPT discontinuation rate was lower in the negative iFOBT group than in the positive iFOBT group (3.4 vs. 18.8%, p=0.005). Kaplan-Meier event-free curves showed that the DAPT discontinuation rate in the negative iFOBT group was lower than that observed in the positive iFOBT group (log-rank test: p=0.001). Logistic and Cox regression analyses showed that a positive iFOBT result was the strongest predictor of the risk of DAPT discontinuation after coronary stenting. Conclusion A positive iFOBT result is associated with DAPT discontinuation following coronary stenting. |
| Databáze: | OpenAIRE |
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