Chronic Recurrent Multifocal Osteomyelitis (CRMO): A Study of 12 Cases from One Institution and Literature Review
| Autor: | Nadeen Zaiat, Eric Chang, Scott Baker, Ereny Demian, Jasmine Vickery, Eman Sallam, Bahig M. Shehata, Janet Poulik, Mohamed Alhamar, Abdul Hanan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Biopsy Single gene Pathology and Forensic Medicine Mice Fibrosis medicine Animals Humans Child medicine.diagnostic_test business.industry Osteomyelitis Medical record Chronic recurrent multifocal osteomyelitis General Medicine Inflammatory bone disease medicine.disease Dermatology Anti-Bacterial Agents Pediatrics Perinatology and Child Health Chronic Disease business Pediatric population |
| Zdroj: | Fetal and pediatric pathology. 41(5) |
| ISSN: | 1551-3823 |
| Popis: | Background CRMO is a sterile auto inflammatory bone disease that affects the pediatric population. Recently, single gene mutations in LPIN2, DIRA, and IL1RN have been reported in murine models of CRMO. Materials and methods The medical records and histopathological slides of twelve patients were reviewed. Results The diagnosis was determined by multiple lesions, imaging, negative cultures, bone biopsy, and lack of antibiotic response. Biopsy showed early neutrophilic infiltrates, and older lesions showed lymphoplasmacytic infiltrates and fibrosis. Patients were treated with anti-inflammatory medication with some lesions completely resolving. Conclusion Bone biopsy aids the diagnosis of CRMO in correlation with clinical presentation, imaging, and culture findings. Our findings indicate the kinetics of CRMO is not well defined and the fibrosis may be reached after months, in contrast to the previously reported several years. We hope that these genetic mutations can be further studied in human models to describe the genetics behind CRMO. |
| Databáze: | OpenAIRE |
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