Zebrafish Trak proteins 1a and 2 localize to the mitochondria

Autor: Kelsey A, Oonk, Lauren B, Bienvenu, Paxton S, Sickler, Christine, Martin, Emily, Nickoloff-Bybel, Albert Matthew, Volk, Douglas C, Weiser, Susan, Walsh
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: microPublication Biology
ISSN: 2578-9430
Popis: Inside a cell, mitochondria are organelles that exhibit dynamic locomotion and spatial rearrangement (Cai and Sheng 2009; Sheng 2017). This movement is necessary for a cell to maintain basic metabolic functions, and disruption of this motility often results in cell death. In fruit flies and mammals, one protein complex is primarily responsible for trafficking mitochondria along microtubules. This protein complex typically, but not always, consists of three proteins: Miro, Trak, and a motor protein (Stowers et al. 2002; Guo et al. 2005; Glater et al. 2006; Macaskill et al. 2009; Koutsopoulos et al. 2010; Brickley and Stephenson 2011; van Spronsen et al. 2013; Barel et al. 2017; López-Doménech et al. 2018; Henrichs et al. 2020).
Databáze: OpenAIRE