A small-molecule screen identifies new functions for the plant hormone strigolactone
| Autor: | Shigeo Toh, Peter McCourt, Danielle Vidaurre, Yuichiro Tsuchiya, Yuji Kamiya, Shinjiro Yamaguchi, Eiji Nambara, Atsushi Hanada |
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| Rok vydání: | 2010 |
| Předmět: |
Genotype
Light Active Transport Cell Nucleus Arabidopsis Strigolactone Germination Computational biology Small Molecule Libraries Lactones Plant Growth Regulators Striga Botany Arabidopsis thaliana Molecular Biology Gene biology Arabidopsis Proteins Nuclear Proteins food and beverages Cell Biology biology.organism_classification Hypocotyl Karrikin Ubiquitin ligase Orobanche Basic-Leucine Zipper Transcription Factors Seedlings Ubiquitin-Conjugating Enzymes biology.protein Plant hormone |
| Zdroj: | Nature Chemical Biology. 6:741-749 |
| ISSN: | 1552-4469 1552-4450 |
| DOI: | 10.1038/nchembio.435 |
| Popis: | Parasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using Arabidopsis thaliana as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed. |
| Databáze: | OpenAIRE |
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