Molecular profiling of sarcomas: new vistas for precision medicine
| Autor: | Neeta Somaiah, Tariq Al-Zaid, Wei Lien Wang, Alexander J. Lazar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Response to therapy medicine.medical_treatment Bioinformatics Pathology and Forensic Medicine Targeted therapy 03 medical and health sciences 0302 clinical medicine New medications medicine Biomarkers Tumor Profiling (information science) Humans Precision Medicine Molecular Biology Heterogeneous group business.industry Gene Expression Profiling Sarcoma Cell Biology General Medicine Precision medicine medicine.disease Molecular diagnostics 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Virchows Archiv : an international journal of pathology. 471(2) |
| ISSN: | 1432-2307 |
| Popis: | Sarcoma is a large and heterogeneous group of malignant mesenchymal neoplasms with significant histological overlap. Accurate diagnosis can be challenging yet important for selecting the appropriate treatment approach and prognosis. The currently torrid pace of new genomic discoveries aids our classification and diagnosis of sarcomas, understanding of pathogenesis, development of new medications, and identification of alterations that predict prognosis and response to therapy. Unfortunately, demonstrating effective targets for precision oncology has been elusive in most sarcoma types. The list of potential targets greatly outnumbers the list of available inhibitors at the present time. This review will discuss the role of molecular profiling in sarcomas in general with emphasis on selected entities with particular clinical relevance. |
| Databáze: | OpenAIRE |
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