Structural and functional reorganization of working memory system during the first decade in schizophrenia. A cross-sectional study

Autor: E Fassio, C. Lançon, Jean-Philippe Ranjeva, Pascal Auquier, Valérie Chanoine, Elisabeth Soulier, Maxime Guye, L. Boyer, Raphaëlle Richieri, Catherine Faget-Agius
Přispěvatelé: Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] (Hôpitaux Sud), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Adult
Male
medicine.medical_specialty
Cross-sectional study
Disease duration
Disease
Neuropsychological Tests
behavioral disciplines and activities
050105 experimental psychology
Statistics
Nonparametric
03 medical and health sciences
Young Adult
[SPI]Engineering Sciences [physics]
0302 clinical medicine
Atrophy
Physical medicine and rehabilitation
medicine
Image Processing
Computer-Assisted
Humans
0501 psychology and cognitive sciences
Progressive atrophy
Longitudinal Studies
Biological Psychiatry
Functional MRI
Psychiatric Status Rating Scales
Brain Mapping
Memory Disorders
Working memory
05 social sciences
Brain
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Oxygen
Psychiatry and Mental health
Cross-Sectional Studies
Memory
Short-Term
Schizophrenia
Female
Functional organization
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Schizophrenia Research
Schizophrenia Research, Elsevier, 2013, 151 (1-3), pp.48-60. ⟨10.1016/j.schres.2013.10.023⟩
Schizophrenia Research, 2013, 151 (1-3), pp.48-60. ⟨10.1016/j.schres.2013.10.023⟩
Europe PubMed Central
ISSN: 0920-9964
DOI: 10.1016/j.schres.2013.10.023⟩
Popis: article i nfo Article history: Introduction: Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. Methods: Twenty-eight patients with schizophrenia (16 with long disease duration (N60 months) and 12 with short disease duration (b60 months)) and eleven healthy controls underwent structural and functional MRI during an n-back task to determine atrophy and activation patterns. Results: At similar n-back performances and relative to short disease duration patients, long disease duration patients activated more frontal temporal parietal and frontal network during 0-back and 1-back tasks respectively. n-back scores were correlated to atrophy in the frontal-temporal areas. Discussion: Functional reorganization in the working memory network may play a compensatory role during the first ten years of schizophrenia.
Databáze: OpenAIRE
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