Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism
| Autor: | Kamyar Asadipooya, Bagher Larijani, Zahra Sanjdideh, Roya Amirinejad, Samad Akbarzadeh, Afshar Bargahi, Ali Movahed, Katayoun Vahdat, Majid Assadi, Mohammadreza Kalantarhormozi, Iraj Nabipour, Maryam Farrokhnia |
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| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteocalcin Population Iran Bone and Bones Bone remodeling Endocrinology Bone Density Diabetes mellitus Internal medicine medicine Humans Orthopedics and Sports Medicine education Abdominal obesity Aged Aged 80 and over Metabolic Syndrome Bone mineral education.field_of_study biology business.industry Type 2 Diabetes Mellitus General Medicine Middle Aged Alkaline Phosphatase medicine.disease Postmenopause C-Reactive Protein Diabetes Mellitus Type 2 biology.protein Female medicine.symptom Metabolic syndrome Energy Metabolism business |
| Zdroj: | Journal of Bone and Mineral Metabolism. 30:683-691 |
| ISSN: | 1435-5604 0914-8779 |
| Popis: | Although it has been shown that osteocalcin functions as a hormone in the regulation of glucose metabolism and fat mass, no population-based study to date has addressed serum osteocalcin levels in relation to energy metabolism concurrent with bone metabolism in postmenopausal women. In a population-based study, cardiovascular risk factors, high-sensitivity C-reactive protein (hs-CRP), osteoprotegerin, receptor activator of nuclear factor-κB ligand, osteocalcin, CrossLaps, alkaline phosphatase, and bone mineral density (BMD) at the lumbar spine (L2–L4) and the proximal femur were measured in 382 Iranian postmenopausal women. In multiple logistic regression analysis, lower osteocalcin and CrossLaps levels were associated with a higher odds ratio (OR) of having type 2 diabetes mellitus when adjustments were made for age, hs-CRP, cardiovascular risk factors, BMD, and markers of bone metabolism [OR 5.17, CI (2.66–10.04), p |
| Databáze: | OpenAIRE |
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