Subretinal electrode implantation in the P23H rat for chronic stimulations
| Autor: | O.P. Linderholm, Marco Pelizzone, Serge Picaud, Daniel Bertrand, J.L. Guyomard, Avinoam B. Safran, Philippe Renaud, J. Salzmann, M. Lecchi, Elisabeth Dubus, José-Alain Sahel, Jörg Sommerhalder, Michel Paques, Manuel Simonutti |
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| Rok vydání: | 2006 |
| Předmět: |
Retinal degeneration
VISUAL-PERCEPTION medicine.medical_specialty Retinal implant Electric Stimulation Therapy Retinal ganglion Prosthesis Implantation PROSTHESIS Cellular and Molecular Neuroscience chemistry.chemical_compound In vivo Ophthalmology RETINITIS-PIGMENTOSA Retinitis pigmentosa medicine Animals Laboratory Science - Extended Report ARTIFICIAL VISION MACULAR Retina ANALYSIS MORPHOMETRIC business.industry Retinal Degeneration Retinal detachment Retinal ELECTRICAL-STIMULATION Anatomy DEGENERATION medicine.disease Sensory Systems Electrodes Implanted Rats DEGENERATED PHOTORECEPTORS Ophthalmoscopy Disease Models Animal medicine.anatomical_structure chemistry OPTIC-NERVE STIMULATION Feasibility Studies RCS RAT sense organs business |
| Zdroj: | British Journal of Ophthalmology. 90:1183-1187 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2005.089110 |
| Popis: | Background: In age related macular degeneration and inherited dystrophies, preservation of retinal ganglion cells has been demonstrated. This finding has led to the development of various models of subretinal or epiretinal implant in order to restore vision. This study addresses the development of a polyimide subretinal electrode platform in the dystrophic P23H rat in vivo. Methods: A technique was developed for implanting a subretinal electrode into the subretinal space and stabilising the distal extremity of the cabling on the rat cranium in order to allow future electrical stimulations of the retina. Results: In vivo imaging of the retina with the scanning laser ophthalmoscope demonstrated reabsorption of the surgically induced retinal detachment and the absence of major tissue reactions. These in vivo observations were confirmed by retinal histology. The extraocular fixation system on the rat cranium was effective in stabilising the distal connector for in vivo stimulation. Conclusion: This study demonstrates that a retinal implant can be introduced into the subretinal space of a dystrophic rat with a stable external connection for repeatable electrical measurements and stimulation. This in vivo model should therefore allow us to evaluate the safety and efficacy of electrical stimulations on dystrophic retina. |
| Databáze: | OpenAIRE |
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