The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies
| Autor: | Li-Rong Zhu, Jun Hu, Xiaobing Jiao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Medicine Humans Stage (cooking) Cervix Neoplasm Staging Cervical cancer Ovarian Neoplasms 030219 obstetrics & reproductive medicine Hysterectomy business.industry Incidence Obstetrics and Gynecology Oophorectomy Odds ratio medicine.disease body regions Observational Studies as Topic medicine.anatomical_structure 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female business Organ Sparing Treatments |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 26(8) |
| ISSN: | 1525-1438 |
| Popis: | ObjectiveThe aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.MethodsTo perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.ResultsA total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14–13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30–68 months); however, 15 patients with SCC developed pelvic recurrence.ConclusionsAlthough the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups. |
| Databáze: | OpenAIRE |
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