Leucocyte-poor-platelet-rich plasma intra-operative injection in chondral knee injuries improve patients outcomes. A prospective randomized trial
| Autor: | João Paulo Fernandes Guerreiro, Daniele Cristina Cataneo, Hamilton da Rosa Pereira, Alexandre Oliveira Queiroz, Marcus Vinicius Danieli |
|---|---|
| Přispěvatelé: | Unort.E Hospital de Ortopedia, Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Knee Joint Chondroplasty Osteoarthritis Knee Injuries Articular cartilage Group B law.invention 03 medical and health sciences Arthroscopy 0302 clinical medicine Randomized controlled trial Platelet-rich plasma law medicine Humans Orthopedics and Sports Medicine Knee Prospective Studies 030203 arthritis & rheumatology 030222 orthopedics medicine.diagnostic_test business.industry Platelet-Rich Plasma Lysholm Knee Score medicine.disease Surgery Treatment Outcome Orthopedic surgery business Knee injuries |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2021-06-25T10:12:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Purpose: Evaluate the effects of intra-operative leucocyte-poor-platelet-rich plasma (PRP) (type P3-Bβ with endogenous activation) injection in International Cartilage Repair Society (ICRS) grade III knee chondral injuries treated by chondroplasties, to increase and ameliorate the repair tissue. Methods: Patients were divided into two groups. Group A (control) consisted of 31 patients and Group B (PRP) 33 patients, totaling 64 patients analyzed. Patients also could had associated injuries (meniscal and/or ACL) being equally divided between both groups to avoid bias. PRP was injected at the end of surgery in group B. The patient outcomes were assessed using subjective International Knee Documentation Committee (IKDC) form, Knee Injury and Osteoarthritis Outcome Score (KOOS), and Tegner activity forms, prior to the surgery and three, six, 12, and 24 months after surgery (medium-term follow up). Results: IKDC and KOOS scores showed increase at each evaluation time points after surgery in both groups, but the treated Group (B) showed a higher increase with statistically significant difference. The Tegner activity scores were higher for the treated group only at six and 12 months. Conclusion: Based on the subjective IKDC, KOOS, and Tegner scores, those patients affected by ICRS grade III chondral injuries undergoing arthroscopic chondroplasty who were also treated with PRP showed better and faster outcomes than the control group. Independently from the associated injury (meniscal or ACL). This difference could be measured for up to two years. Unort.E Hospital de Ortopedia, Av. Higienópolis no 2600 Departamento de Cirurgia Faculdade de Medicina Universidade Estadual Paulista (UNESP) Departamento de Cirurgia Faculdade de Medicina Universidade Estadual Paulista (UNESP) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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