Normal-sized basal ganglia perivascular space related to motor phenotype in Parkinson freezers
| Autor: | Baorong Zhang, Wenying Zhang, Yaxing Gui, Fang Ba, Lili Chen, Ting Shen, Wen Lv, Hsin Yi Lai, Fei Xie, Xingyue Hu, Yumei Yue |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Levodopa Parkinson's disease Thalamus 7T MRI Basal Ganglia Midbrain Internal medicine Basal ganglia Centrum semiovale Humans Medicine Perivascular space Gait Gait Disorders Neurologic Aged business.industry Parkinson Disease perivascular spaces Cell Biology Middle Aged medicine.disease Magnetic Resonance Imaging motor phenotype Phenotype medicine.anatomical_structure Cardiology Female business Research Paper medicine.drug |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.203343 |
| Popis: | Changes in basal ganglia (BG) perivascular spaces (PVSs) are related to motor and cognitive behaviors in Parkinson's disease (PD). However, the correlation between the initial motor phenotype and PVSs distribution/burden in PD freezing of gait (FOG) remains unclear. In addition, the normal-sized PVSs (nPVSs) have not been well-studied. With high-resolution 7T-MRI, we studied nPVSs burden in BG, thalamus, midbrain and centrum semiovale. The numbers and volume of nPVSs were assessed in 10 healthy controls, 10 PD patients without FOG, 20 with FOG [10 tremor dominant (TD), 10 non-TD subtype]. Correlation analyses were further performed in relation to clinical parameters. In this proof of concept study, we found that the nPVS burden of bilateral and right BG were significantly higher in freezers. A negative correlation existed between the tremor score and BG-nPVSs count. A positive correlation existed between the levodopa equivalent daily dose and BG-nPVSs count. The nPVS burden correlated with the progression to FOG in PD, but the distribution and burden of nPVS differ in TD vs. non-TD subtypes. High resolution 7T-MRI is a sensitive and reliable tool to evaluate BG-nPVS, and may be a useful imaging marker for predicting gait impairment that may evolve into FOG in PD. |
| Databáze: | OpenAIRE |
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