Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome
| Autor: | Alcyone Artioli Machado, N. H. S. Deghaide, L. Castelar, Ana Paula Morais Fernandes, M. M. Silva, Erick C. Castelli, Celso T. Mendes-Junior, Eduardo Antônio Donadi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Immunology Single-nucleotide polymorphism HIV Infections Biology Biochemistry Polymorphism Single Nucleotide Interferon-gamma Antiretroviral Therapy Highly Active Genotype Genetics medicine Immunology and Allergy SNP Humans Interferon gamma Genetic Predisposition to Disease Allele DNA Primers Base Sequence HIV-Associated Lipodystrophy Syndrome Haplotype Interleukin-18 General Medicine Middle Aged medicine.disease Virology Haplotypes Case-Control Studies HIV-1 Interleukin 18 Female Lipodystrophy Brazil medicine.drug |
| Zdroj: | Tissue antigens. 76(2) |
| ISSN: | 1399-0039 |
| Popis: | Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions -607(C/A) and -137(C/G) in the promoter region of the interleukin-18 (IL-18) gene and at position +874(T/A) of the interferon-gamma (IFN-gamma) gene are related to the expression of these cytokines. To examine whether IL-18 and IFN-gamma polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)-infected patients presenting LS, 79 HIV-infected without LS, and 133 healthy controls. The -607A allele, -607AA genotype, and -137G/-607A and -137C/-607A haplotypes in the IL-18 gene were over-represented in HIV patients presenting LS. The -137G/-607C haplotype was associated with protection against LS. These results indicate that the -607(C/A) SNP is associated with LS development in HIV-infected patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|