Correlation Between Plasma Oligomeric Amyloid-β and Performance on the Language Neutral Visual Cognitive Assessment Test in a Southeast Asian Population

Autor:	Gurveen Kaur Sandhu, Fatin Zahra Zailan, Ashwati Vipin, Soo See Ann, Dilip Kumar, Kok Pin Ng, Nagaendran Kandiah
Rok vydání:	2022
Předmět:	Psychiatry and Mental health Clinical Psychology Amyloid beta-Peptides Cognition Alzheimer Disease General Neuroscience Humans Cognitive Dysfunction General Medicine Neuropsychological Tests Geriatrics and Gerontology Biomarkers Language
Zdroj:	Journal of Alzheimer's Disease. 89:25-29
ISSN:	1875-8908 1387-2877
Popis:	Oligomeric amyloid-β (OAβ), an upstream driver of Alzheimer’s disease (AD) neuropathology, correlates with poor cognitive performance and brain volume reduction. Its effect on cognitive performance measured by the language neutral Visual Cognitive Assessment Test (VCAT) remains to be evaluated. We studied the correlation of plasma OAβ with VCAT scores and grey matter volume (GMV) in a Southeast Asian cohort with mild cognitive impairment. Higher plasma OAβ significantly correlated with lower; cognitive scores (VCAT, Mini-Mental State Examination) and GMV/intracranial volume ratio. Such findings reveal the clinical utility of plasma OAβ as a promising biomarker and support validation through longitudinal studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25011d1dd3be4cc7ef3b939e6074445a https://doi.org/10.3233/jad-220484 Zobrazit plný text záznamu