MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis
| Autor: | Jing Yang, Miguel Santiago-Medina |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology and Carcinogenesis macromolecular substances Haptotaxis Metastasis 03 medical and health sciences Cell Movement Neoplasms Cell Adhesion medicine Humans Cell adhesion biology Chemistry Chemotaxis Cancer Fibrillogenesis medicine.disease Fibronectins Fibronectin 030104 developmental biology Oncology Immunology biology.protein Cancer research Signal transduction Integrin alpha5beta1 Signal Transduction |
| Zdroj: | Cancer discovery, vol 6, iss 5 |
| ISSN: | 2159-8290 2159-8274 |
| DOI: | 10.1158/2159-8290.cd-16-0231 |
| Popis: | Summary: Oudin and colleagues report a novel and specific function of MENA in mediating directional migration of breast cancer cells toward a fibronectin gradient of increasing concentration. This MENA-mediated haptotactic response depends on the binding of MENA to the α5β1 integrin receptor, adhesion protein signaling, and fibronectin fibrillogenesis. Cancer Discov; 6(5); 474–6. ©2016 AACR. See related article by Oudin et al., p. 516. |
| Databáze: | OpenAIRE |
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