Effect of transdermal oestradiol on the haemostatic balance of menopausal women
| Autor: | John Stuart, Gillian K. Stuart, A. John George, Janet Fox, John R. Newton, Anthony D. Parsons, David W. Sturdee |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Platelet Aggregation medicine.drug_class medicine.medical_treatment Administration Cutaneous General Biochemistry Genetics and Molecular Biology Internal medicine medicine Humans Prospective Studies Prospective cohort study Blood Coagulation Transdermal Gynecology Chemotherapy Hemostasis Estradiol business.industry Fibrinolysis Obstetrics and Gynecology Hormone replacement therapy (menopause) Middle Aged medicine.disease Blood Viscosity Thrombosis Blood Coagulation Factors Menopause Estrogen Female business Hormone |
| Zdroj: | Maturitas. 18(1) |
| ISSN: | 0378-5122 |
| Popis: | Objective: To determine the effect of transdermal oestrogen replacement therapy on the haemostatic balance of menopausal women. Design: Open, parallel group, prospective study. Setting: Three hospital-based menopause clinics. Subjects: Fifty-two postmenopausal women receiving transdermal hormone replacement therapy (Estrapak 50) for 6 months. Comparison group of 48 untreated postmenopausal women studied in parallel. Main outcome measures: Changes in platelet number, plasma concentrations of coagulation factors and their natural inhibitors, fibrinolytic activity, and theological parameters. Results: Estrapak 50 had no significant thrombophilic effect on any of the outcome measures. Conclusion: The haemostatic balance and thus the risk of thrombosis would not appear to be upset by this dose of transdermal oestrogen. |
| Databáze: | OpenAIRE |
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