Prognostic Utility of Fatty Acid-Binding Protein 4 in Patients with Type 2 Diabetes and Acute Ischemic Stroke
| Autor: | Weina Zhao, Changhao Yin, Siou Li, Pengxiang Bi, Quankui Wang, Dan Xu, Jiayuan Ding, Yifei Lian, Haifu Zhu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Multivariate statistics Neurology Multivariate analysis Type 2 diabetes 030204 cardiovascular system & hematology Toxicology Logistic regression Fatty Acid-Binding Proteins Brain Ischemia 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Neurochemistry Aged business.industry General Neuroscience Middle Aged medicine.disease Prognosis Confidence interval Surgery Stroke Quartile Diabetes Mellitus Type 2 Female business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Neurotoxicity research. 33(2) |
| ISSN: | 1476-3524 |
| Popis: | The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum fatty acid-binding protein 4 (FABP4) could be a prognostic factor in Chinese patients with type 2 diabetes (T2DM) and acute ischemic stroke (AIS). From September 2015 to August 2016, consecutive first-ever AIS patients combined with T2DM were included in this study. FABP4, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcomes within 3 months. Multivariate analyses were performed using logistic regression models. We measured FABP4 in 329 patients. The median age of patients included in this study was 63 (IQR, 56–72) years and 45.9% were women. FABP4 serum levels were obtained at a median of 8.5 h (IQR, 4.0–14.0 h) after the stroke onset with a median value of 21.4 ng/ml (IQR, 15.6–28.2 ng/ml). In multivariable models, FABP4 remained an independent stroke severity predictor with an adjusted OR of 1.05 (95% CI, 1.02–1.09). In multivariate models comparing the third (odd ratio (OR), 2.25; 95% confidence interval (CI), 1.59–3.54) and fourth quartiles (OR, 3.75; 95% CI, 2.48–5.03) against the first quartile of the FABP4, levels of FABP4 were associated with poor functional outcome. At 3 months, 38 patients (11.6%; 95%CI, 8.1–15.0%) had died. The mortality distribution across the FABP4 quartiles ranged between 3.7% (first quartile) and 20.7% (fourth quartile). Elevation of FABP4 is associated with an increased risk of death and poor functional outcome events in patients with type 2 diabetes and acute ischemic stroke and is independent of other established clinical risk predictors and biomarkers. |
| Databáze: | OpenAIRE |
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