Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study
| Autor: | Haifa Tounsi Guettiti, Leila Attia, Nissaf Ben Alaya, Samir Boubaker, Dalenda Chelly, Emna Ennaifer, Rim Ben Aissa, Thalja Laassili |
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| Přispěvatelé: | Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Department of Gynecology, Hopital Charlles Nicolle de Tunis, Department of Gynecology Centre de maternité et de Néonatologie Tunis, Centre de maternité et de Néonatologie Tunis, Department of Epidemiology, Observatoire National de Tunis, Observatoire National de Tunis, Family Planning Clinic of Ariana Tunis, Tunisia, Laboratoire d’Anatomie Pathologique Humaine et Expérimentale, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This work was supported by grants from the Ministry, of Health 'research unit on Human papillomavirusinfection'. It was carried out in the Who HPV LabNet regional reference Laboratory Who Eastern Mediterranean region, department of Pathology at the Institut Pasteur de Tunis. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Urban Population Epidemiology Cross-sectional study [SDV]Life Sciences [q-bio] Uterine Cervical Neoplasms Odds Ratio Prevalence Mass Screening Medicine Young adult Papillomaviridae vaccination strategy medicine.diagnostic_test Obstetrics Vaccination HPV infection virus diseases Middle Aged female genital diseases and pregnancy complications 3. Good health Oncology [SDV.IMM]Life Sciences [q-bio]/Immunology Female Risk assessment Papanicolaou Test Adult medicine.medical_specialty Human papillomavirus Tunisia Adolescent Genotype Risk Assessment Young Adult Age Distribution Confidence Intervals Humans Papillomavirus Vaccines Pap test Developing Countries Genotyping Aged Gynecology pap smears business.industry Papillomavirus Infections Public Health Environmental and Occupational Health Odds ratio medicine.disease Cross-Sectional Studies Logistic Models urban Tunis [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention Asian Pacific Journal of Cancer Prevention, Asian Pacific Education Press Ltd., 2014, 15 (21), pp.9361. ⟨10.7314/APJCP.2014.15.21.9361⟩ |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/APJCP.2014.15.21.9361⟩ |
| Popis: | International audience; To estimate the pre-vaccination distribution of human papillomavirus (HPV) types amongwomen from urban Tunis. Materials and Methods: A total of 611 women aged 18-69 years were enrolled inthree local gynaecological outpatient departments. All underwent a gynaecological examination with Pap testand dry swab for HPV detection and typing performed by linear array genotyping test (Roche). Cytologicalexamination was conducted on conventional Pap smears. Results: HPV DNA was found in 6.5% of the women;the most frequent HPV types were HPV 16 and HPV 11 at 3.27% and 1.96%, respectively. The second mostfrequent high risk (HR) HPV type was HPV 58 (0.82%) followed by HPV 18, HPV 31 and HPV 33 found inonly 0.33% of women. Single infections with HPV types, targeted by the quadrivalent vaccine (6, 11, 16, and18), were detected in 3.6 % of the study patients (55% of positive women). HPV infection was found in 3.83% ofwomen with normal cytology and in 47.4% of women with cytological abnormalities. No statistically significanttrend in prevalence by age group emerged for any HPV type or for high or low risk types. Conclusions: Thesedata show a relatively low prevalence of HPV infection in women from urban Tunis with a high proportion ofHPV16 and HPV58. This should be considered in the upcoming screening programs and vaccination strategy. |
| Databáze: | OpenAIRE |
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