Design of a novel class of biphenyl CETP inhibitors

Autor:	Suzanne S. Eveland, Laurence B. Peterson, Carl P. Sparrow, Zhijian Lu, Denise P. Milot, Amjad Ali, Joann B. Napolitano, Qiu Guo, Sheryl A. Hyland, Eugene Tan, Suoyu S. Xu, Samuel D. Wright, Ying Chen, Milton L. Hammond, Melanie Latham, Peter J. Sinclair, Ashleigh B. Theberge, Matt S. Anderson, Xinchun Tong
Rok vydání:	2010
Předmět:	Genetically modified mouse Benzylamines Clinical Biochemistry Pharmaceutical Science Mice Transgenic Biochemistry Chemical synthesis Mice Structure-Activity Relationship In vivo Drug Discovery Cholesterylester transfer protein Animals Structure–activity relationship Molecular Biology chemistry.chemical_classification biology Biphenyl Compounds Organic Chemistry In vitro Cholesterol Ester Transfer Proteins Biphenyl compound Disease Models Animal chemistry Drug Design biology.protein Molecular Medicine lipids (amino acids peptides and proteins) Carbamates Lipoproteins HDL Glycoprotein
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 20:7469-7472
ISSN:	0960-894X
Popis:	A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd2ff15715d0d6f5760db6460b5c89 https://doi.org/10.1016/j.bmcl.2010.10.019 Zobrazit plný text záznamu Full Text from ScienceDirect